SAM-e (S-Adenosyl Methionine, Ademethionine, Adomet) is found in almost every cell in the human body as an amino acid bound to the ATP, and affects many aspects of our health. Our bodies synthesize SAMe in the liver, and taking SAMe supplements can help with many bodily functions.
Through a process called methylation, this molecule assists in the manufacture and breakdown of the neurotransmitter dopamine, acetylcholine, serotonin, melatonin, and norepinephrine in the brain. It essentially slows the breakdown of these chemicals which allows them to work longer. SAMe also speeds up the production of the receptors that receive these neurotransmitters. These extra receptors help the neurotransmitters work more productively. SAMe also plays a role in immune system health and maintains cell meme brains.
There are no foods that are high in SAMe, so the body must make it in the liver from the amino acid methionine. Although methionine is found in many foods, supplementing with methionine isn’t very effective because creating SAMe takes many steps and requires multiple co-factors, like B12 and folate, for the process to be successful.
SAMe participates in over 35 biochemical processes in the body, but most research shows that the primary way SAMe benefits cognition is in relation to depressive symptoms. One study on patients diagnosed with Parkinson’s found that SAMe reduced the symptoms of depression by 65%. In another study, SAMe was found to treat the symptoms of depression as well as prescription drugs like SSRIs. People with depression often have lower than average levels of SAMe, and in some cases, this molecule work better for depressed patients than SSRIs. SAMe was also shown to relieve depression symptoms in people who don’t respond to SSRIs and might be an excellent alternative antidepressant for people who can’t tolerate their side effects. The molecule also works much faster at reducing depression symptoms than SSRIs, which can take from 6 to 8 weeks to start working.
SAMe can also benefit the brain by improving cognition. It is thought to work by increasing creatine (energy) levels in parts of the brain and could improve cognition the same way creatine does. SAMe can also be helpful for the brain by boosting memory, learning, and neuroprotection by working to improve cholinergic functioning. With continued use, this action could improve functions like learning ability and memory formation, as well as protecting against the negative effects of aging like dementia and Alzheimer’s.
SAMe is considered a very mild nootropic drug with few risks, and very safe at recommended doses between 800mg/day and 1600mg/day. It has no real side effects because it is essentially a protein. Although, it can upset the stomach, and in one rare case study it triggered mania in a patient with bipolar disorder. Like any chemical that affects the neurotransmitter serotonin, there is a small risk of developing serotonin syndrome when supplementing with SAMe. But with recommended doses, SAMe is a safe and effective nootropic compound that can improve brain and overall health.