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Thrivous Upgrades Clarity with Bioavailable Vitamin B Complex

Thrivous Administrator Nootropics Product Announcement



Thrivous Clarity, the Daily Nootropic

Orem UT – Thrivous, a human enhancement company, has upgraded Clarity, the daily nootropic, to include bioavailable Vitamin B Complex. Clarity is a cognitive enhancement supplement that Thrivous developed to improve focus, memory, and mood. Thrivous designed formula 2 of Clarity to support brain function and complement other nootropics that Thrivous developed and brought to market since launching the previous formula.

"I'm excited to announce Clarity formula 2," said Lincoln Cannon, CEO at Thrivous. "Thrivous has expanded its line of nootropics to offer superior supplementation strategies for some of the ingredients that were in Clarity formula 1. So now we can combine the nootropic benefits of Clarity's main ingredients, Bacopa and Rhodiola, with the brain function support benefits of Vitamin B Complex."

Guided by science, Thrivous identifies nootropics with the greatest potential to promote mental performance beyond what can be achieved through traditional lifestyle choices alone. Clarity contains ingredients at concentrations and amounts based on high levels of evidence for notable effect from peer-reviewed, double-blind, placebo-controlled studies on humans.

Thrivous makes Clarity from substances in the human diet, including vitamins, minerals, and herbs. It does not contain substances derived from animals. All ingredients and capsules are vegan.

Clarity now includes Vitamin B Complex to support brain function. Thrivous carefully selected bioavailable forms of the B Vitamins. For example, L-5-Methyltetrahydrofolate is a B9 vitamer that may be more effective than typical Folic Acid, particularly for persons with the MTHFR gene mutation. Adenosylcobalamin and Methylcobalamin are B12 vitamers that may be more effective than Cyanocobalamin. And Sulbutiamine is a dimer of B1 that may traverse the blood-brain barrier better than other forms of Thiamin.

Clarity continues to include Bacopa, Rhodiola, and Zinc, with clinical doses of their primary bioactive constituents. The recommended serving of two capsules provides 150 mg bacoside (from 600 mg of Bacopa Monnieri), 6 mg salidroside (from 300 mg of Rhodiola Rosea), and 11 mg of Zinc (100% of the daily recommended value). At these dosages, Bacopa may increase memory, Rhodiola may improve focus and mood, and Zinc may support mood.

Thrivous publishes the Clarity formula openly and completely, and strives to improve the formula continuously. This contrasts sharply with the practices of many vendors, who hide their product formulas behind proprietary blends. The open-source formula identifies all ingredients and their dosages, which is the only way for consumers to know what and how much they are using, so that they may make good decisions. Because science is never finished, Thrivous continuously monitors and reviews new studies, consults with its advisor board of physicians and scientists, and updates the Clarity formula accordingly.

Thrivous publishes a certificate of analysis and quality for Clarity, sharing all test results from suppliers and manufacturers. This is exceptional among vendors, who often withhold test results or make them difficult to find. Suppliers subject each ingredient to stringent quality testing, including identity, potency, microbial, heavy metals, and other testing as appropriate prior to release for manufacturing. Manufacturers follow strict GMP regulation from the FDA in audited and certified facilities. They monitor production and test finished product to ensure quality prior to release for shipping.

The original Clarity formula included Ginkgo, Ginseng, and L-Theanine. To facilitate superior supplementation strategies, Thrivous has moved Ginkgo into Alpha, Ginseng into Surge, and L-Theanine into both Surge and Serenity.

Ginkgo Biloba is now available in Alpha, the extended daily nootropic. Alpha combines ingredients that lend themselves to long-term nootropic effect via single or multiple daily doses. Moving Ginkgo from Clarity to Alpha enables greater flexibility in Ginkgo supplementation strategy for Thrivous customers.

Panax Ginseng is now available in Surge, which Thrivous designed to increase energy and focus. Surge combines ingredients that lend themselves to acute supplementation, occasional rather than daily use, to preserve a greater nootropic effect over time. Clinical studies also indicate that Ginseng may complement the nootropic effect of Caffeine, which is one of the other ingredients in Surge. Moving Ginseng from Clarity to Surge increases the overall value of Ginseng supplementation for Thrivous customers.

L-Theanine is now available in both Surge and Serenity, the nightly nootropic. Clinical studies indicate that L-Theanine may mitigate the side effects that some people experience with Caffeine, thereby improving the effect of Surge. In addition, when supplemented without a stimulant, L-Theanine may promote relaxation, thereby facilitating the function of Serenity, which Thrivous designed to promote calm, sleep, and next-day focus. Moving L-Theanine from Clarity to both Surge and Serenity improves the targeting of L-Theanine supplementation for Thrivous customers.

Statements in this press release have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a physician before and during use.

Product Webpage

https://thrivous.com/products/clarity-natural-nootropic

Certificate of Analysis and Quality

https://cloud.thrivous.com/downloads/clarity-coaq-formula-2-20170220.pdf 

Related Studies

  1. B Vitamins and the Brain: Mechanisms, Dose and Efficacy – A Review. In 2016, this review concluded that “administration of the entire B-vitamin group, rather than a small sub-set, at doses greatly in excess of the current governmental recommendations, would be a rational approach for preserving brain health”.

  2. Multivitamins and minerals modulate whole-body energy metabolism and cerebral blood-flow during cognitive task performance: a double-blind, randomised, placebo-controlled trial. In 2016, this double-blind, placebo-controlled study found that “brain function and metabolism are amenable to micronutrient supplementation, even in adults who are assumed to have nutritional status typical of the population”.

  3. Effects of Four-Week Supplementation with a Multi-Vitamin/Mineral Preparation on Mood and Blood Biomarkers in Young Adults: A Randomised, Double-Blind, Placebo-Controlled Trial. In 2015, this double-blind, placebo-controlled study found that “supplementation [including high dose B Complex] may have beneficial effects on mood, underpinned by elevated B-vitamins and lowered homocysteine in healthy young adults”.

  4. Acute mood but not cognitive improvements following administration of a single multivitamin and mineral supplement in healthy women aged 50 and above: a randomised controlled trial. In 2015, this placebo-controlled study found that “supplementation with a single multivitamin, mineral and herbal supplement [including high dose B Complex] reduces stress several hours after intake in healthy older people”.

  5. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial. In 2015, this study found that Rhodiola, "although less effective than sertraline, [Rhodiola] may possess a more favorable risk to benefit ratio for individuals with mild to moderate depression".

  6. Zinc Monotherapy Increases Serum Brain-derived Neurotrophic Factor (BDNF) Levels And Decreases Depressive Symptoms In Overweight Or Obese Subjects: A Double-blind, Randomized, Placebo-controlled Trial. In 2015, this study found that "Zinc monotherapy improves mood in overweight or obese subjects".

  7. Effects of multivitamin, mineral and herbal supplement on cognition in younger adults and the contribution of B group vitamins. In 2014, this double-blind, placebo-controlled study found that “supplementation [including high dose B Complex] may be useful for maintaining levels of B vitamins [and] the effects of multivitamins on speeded attention such as the stroop task in young [male] adults warrant further investigation”.

  8. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. In 2014, this meta-analysis found that Bacopa "has the potential to improve cognition, particularly speed of attention".

  9. Effects Of Zinc Supplementation On Efficacy Of Antidepressant Therapy, Inflammatory Cytokines, And Brain-derived Neurotrophic Factor In Patients With Major Depression. In 2014, this study found that "Zinc supplementation in conjunction with antidepressant drugs might be beneficial for reducing depressive symptoms".

  10. Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: a meta-analysis. In 2013, this meta-analysis of eight studies found that “micronutrient supplementation has a beneficial effect on perceived stress, mild psychiatric symptoms, and aspects of everyday mood in apparently healthy individuals [and] supplements containing high doses of B vitamins may be more effective in improving mood states”.

  11. The effects of multivitamin supplementation on diurnal cortisol secretion and perceived stress. In 2013, this double-blind, placebo-controlled study found “a significant interaction … between treatment group and study visit for the Cortisol Awakening Response (CAR) … a possible interpretation of the elevation in CAR associated with multivitamin supplementation [including high dose B Complex] is that this represents an adaptive response to everyday demands in healthy participants … the finding of correlation between CAR and serum B-vitamin levels in the blood in the current study provides strong evidence to suggest that B-vitamins were at least a necessary constituent required to modulate the CAR response”.

  12. The effects of multivitamin supplementation on mood and general well-being in healthy young adults. A laboratory and at-home mobile phone assessment. In 2013, this study found “significantly reduced stress, physical fatigue and anxiety in the [multivitamin including high dose B Complex] group in comparison to placebo across a number of time points”.

  13. Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modafinil: a review and comparison of effect sizes. In 2013, this meta-analysis found that "neurocognitive enhancement from [Bacopa] can produce cognition enhancing effects of similar magnitude to those from pharmaceutical interventions".

  14. Participant experiences from chronic administration of a multivitamin versus placebo on subjective health and wellbeing: a double-blind qualitative analysis of a randomised controlled trial. In 2012, this double-blind, placebo-controlled study found “a range of subjective beneficial effects that are consistent with quantitative data from previously published randomised controlled trials examining the effects of multivitamins and [high dose] B vitamin complexes on mood and well-being”.

  15. Effects of a multivitamin, mineral and herbal supplement on cognition and blood biomarkers in older men: a randomised, placebo-controlled trial. In 2012, this double-blind, placebo-controlled study found that “Levels of vitamin B(12) and folate were significantly increased with a concomitant decrease in homocysteine, indicating that relatively short-term supplementation with a multivitamin [including high dose B Complex] can benefit these risk factors for cognitive decline [and] daily multivitamin supplementation may improve episodic memory in older men at risk of cognitive decline”.

  16. Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement: A randomized controlled trial. In 2012, this double-blind, placebo-controlled study found that “Sixteen weeks supplementation with a combined multivitamin, mineral and herbal formula [including high dose B Complex] may benefit working memory in elderly women at risk of cognitive decline”.

  17. Neurocognitive effects of multivitamin supplementation on the steady state visually evoked potential (SSVEP) measure of brain activity in elderly women. In 2012, this double-blind, placebo-controlled study found that “in the elderly, multivitamin supplementation [including high dose B Complex] may enhance neural efficiency during memory retrieval”.

  18. The effects of multivitamins on cognitive performance: a systematic review and meta-analysis. In 2012, this meta-analysis found that “multivitamins were found to enhance immediate free recall memory but no other cognitive domains”.

  19. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study. In 2012, this study found that Rhodiola "is safe and effective in improving life-stress symptoms to a clinically relevant degree".

  20. Vitamins and cognition: what is the evidence? In 2011, this analysis found that “whereas studies involving supplementation with single vitamins, or restricted ranges of vitamins, have demonstrated equivocal results, evidence from studies involving the administration of broader ranges of vitamins, or multivitamins, suggest potential efficacy in terms of cognitive and psychological functioning”.

  21. The effect of 90 day administration of a high dose vitamin B-complex on work stress. In 2011, this double-blind, placebo-controlled study found that “[high dose] vitamin B complex treatment groups reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks”.

  22. Vitamins and psychological functioning: a mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. In 2011, this double-blind, placebo-controlled study found that “participants in the vitamin/mineral group rated themselves as having greater 'physical stamina' [and] they also rated themselves as having had greater 'concentration' and 'mental stamina' [and] participants in this group also reported greater subjective 'alertness' … healthy members of the general population may benefit from augmented levels of vitamins/minerals via direct dietary supplementation”.

  23. The effect of multivitamin supplementation on mood and stress in healthy older men. In 2011, this double-blind, placebo-controlled study found that “supplementation with a multivitamin, mineral and herbal formulation [including high dose B Complex] may be useful in improving alertness and reducing negative mood symptoms and may also improve feelings of general day-to-day well-being”.

  24. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. In 2010, this double-blind, placebo-controlled study found that “healthy members of the general population may benefit from augmented levels of vitamins/minerals [including high dose B Complex] via direct dietary supplementation [and] supplementation led to improved ratings of stress, mental health and vigour and improved cognitive performance during intense mental processing”.

  25. Effects of a multi-vitamin/mineral supplement on cognitive function and fatigue during extended multi-tasking. In 2010, this double-blind, placebo-controlled study found that “the vitamin/mineral [including B Complex] group exhibited an attenuation of the negative effects of extended task completion on mood/fatigue. Multi-tasking performance for this group was also improved in terms of accuracy across all tasks, and on two of the individual tasks (Mathematical Processing and Stroop) in terms of both faster and more accurate responses [and] healthy members of the general population may benefit from augmented levels of vitamins/minerals via direct dietary supplementation”.

  26. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. In 2010, this study found that "Bacopa significantly improved memory acquisition and retention in healthy older Australians".

  27. Effect Of Zinc Supplementation On Mood States In Young Women: A Pilot Study. In 2010, this study found that Zinc "supplementation may be effective in reducing anger and depression".

  28. The influence of adaptogens on ultraweak biophoton emission: a pilot-experiment. In 2009, this study found that "after supplementation, a significant decrease concerning the experienced level of fatigue in the Rhodiola group was observed".

  29. Zinc Supplementation Augments Efficacy Of Imipramine In Treatment Resistant Patients: A Double Blind, Placebo-controlled Study. In 2009, this study found that "zinc supplementation significantly reduced depression scores and facilitated the treatment outcome in antidepressant treatment resistant patients".

  30. Cognitive and mood effects in healthy children during 12 weeks' supplementation with multi-vitamin/minerals. In 2008, this double-blind, placebo-controlled study found that “vitamin/mineral supplementation [including low dose B Complex] has the potential to improve brain function in healthy children”.

  31. Comparative study of Rhodiola preparations on behavioral despair of rats. In 2008, this animal study found that "Rhodioloside [salidroside], and tyrosol were identified as active principles of the extract, whereas rosavin, rosarin, rosin, cinnamic alcohol, cinnamaldehyde, cinnamic acid were inactive".

  32. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. In 2008, this study found that Bacopa "is efficacious in subjects with age-associated memory impairment".

  33. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. In 2008, this study found that Bacopa "significantly improved performance on the 'Working Memory' factor, more specifically spatial working memory accuracy [and] the number of false-positives recorded in the Rapid visual information processing task was also reduced".

  34. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. In 2008, this study found that Bacopa "has potential for safely enhancing cognitive performance in the aging".

  35. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. In 2007, this study found that Rhodiola "shows anti-depressive potency in patients with mild to moderate depression".

  36. Effect of B vitamins-fortified foods on primary school children in Beijing. In 2006, this study found that "The effect of B vitamin compound supplementation is better than that of single riboflavin supplementation ... [and] micronutrient supplementation appears to assist children's study abilities".

  37. Acute Rhodiola rosea intake can improve endurance exercise performance. In 2004, this study found that Rhodiola "can improve endurance exercise capacity in young healthy volunteers".

  38. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. In 2003, this study found that Rhodiola had "a pronounced antifatigue effect".

  39. Chronic effects of Brahmi (Bacopa monnieri) on human memory. In 2002, this study found that Bacopa "decreases the rate of forgetting of newly acquired information".

  40. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. In 2001, this study found that Bacopa "may improve higher order cognitive processes that are critically dependent on the input of information from our environment such as learning and memory".

  41. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. In 2000, this study found that "the most significant improvement in the [Rhodiola] group was seen in physical fitness, mental fatigue and neuro-motoric tests ... [and] the self-assessment of the general well-being was also significantly better".

  42. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. In 2000, this study found that Rhodiola "can reduce general fatigue under certain stressful conditions".

About Thrivous

Thrivous is a human enhancement company. Its mission is to help people access technology with the greatest potential to improve their brains and bodies. In pursuit of that mission, it develops and distributes nootropics, including Clarity, the daily nootropic to improve focus, memory, and mood, and to support brain function. For more information, please contact support@thrivous.com.



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