Alpha-GPC for Healthy Brain Aging

13 December 2017
Lincoln Cannon

Brain Aging Clocks

Alpha-GPC, also known as alpha-glycerophosphocholine or choline alfoscerate, is a choline compound that occurs naturally in the human brain. Supplementation with Alpha-GPC may provide both nootropic and geroprotective effects, supporting healthy cognitive function as the brain ages, according to these clinical studies on humans:

These clinical study reviews confirm that supplementation of Alpha-GPC may support healthy brain aging:

Among alternatives, Alpha-GPC may be the most bioavailable source of choline for the brain. Common alternatives include Phosphatidylcholine and CDP. According to these studies, Phosphatidylcholine may be less effective at reaching the brain, and CDP may be less efficient per dose:

One way to improve the nootropic effect of Alpha-GPC may be to combine it with Acetyl-L-Carnitine (ALCAR). ALCAR and choline supplementation in combination may be more bioavailable, according to these studies:

When selecting an Alpha-GPC supplement, look for one that facilitates dosages that correspond to clinical studies on humans. This may provide the greatest potential for nootropic and geroprotective effect. In the studies cited above, Alpha-GPC dosages range from 400 mg to 1200 mg, divided into multiple daily doses.

Unfortunately, it is difficult to ascertain the amount of Alpha-GPC in most supplements. Vendors of Alpha-GPC generally use a 50% Alpha-GPC material to facilitate encapsulation. In the Supplement Facts section of their product labels, some products list the amount of 50% Alpha-GPC material rather than the actual amount of Alpha-GPC. Consequently, if you're not careful, you may get only half as much Alpha-GPC as you intended to buy.

Based on the studies cited above and other studies, Thrivous developed Alpha, the neuroprotector. Alpha's ingredients include 300 mg of Alpha-GPC from 600 mg of 50% Alpha-GPC material (as well as 500 mg of Acetyl-L-Carnitine) per serving. Thrivous recommends 1 to 4 servings of Alpha per day, for an Alpha-GPC dosage of 300 mg to 1200 mg daily, which reflects dosages in clinical studies. Accordingly, supplementation of Alpha may support healthy brain aging. Talk to your doctor about starting Alpha today!

Buy Thrivous Alpha Neuroprotector