Welcome to Thrivous!

Enhance Cognitive Longevity with Omega 3

18 March 2024
Thrivous Admin

As scientific inquiry advances, the quest for enhancing human health continues to evolve, investigating not only treatments for disease but also opportunities to improve cognitive function among older adults. One such avenue is the exploration of omega-3 polyunsaturated fatty acids (PUFAs), recognized for their potential in benefiting those with late-life depression (LLD).

A recent clinical trial, titled "Cognitive protection and brain entropy changes from omega-3 polyunsaturated fatty acids supplement in late-life depression: A 52-week randomized controlled trial," sheds light on the complex relationship between omega-3 PUFAs, cognitive function, and brain health in individuals with LLD. This comprehensive study, available at ScienceDirect, highlights the nuanced effects of omega-3 supplements in cognitive preservation and the understanding of brain function changes.

The trial's findings are particularly pertinent given the rising awareness of LLD's association with an increased risk of dementia. Traditional antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), have shown promise in delaying cognitive decline in patients with mild cognitive impairment. However, recent investigations suggest that omega-3 PUFAs could offer a dual effect on both mood and cognitive health, potentially fostering an environment conducive to improved brain functionality. These supplements may enhance neuroprotective processes, decrease inflammation, and thus contribute to maintaining cognitive faculties as age progresses.

Study Design

In a rigorous approach to understanding the effects of omega-3 PUFAs on the aging brain, researchers embarked on a 52-week double-blind randomized controlled trial. Older adults diagnosed with late-life depression were chosen as the focus group for this study, assessing cognitive changes that omega-3 supplementation could potentially foster. The use of resting-state functional MRI (rs-fMRI) scans before and after supplementation offered the researchers a detailed picture of how these fatty acids could affect brain entropy - a measure of predictability and complexity in brain activity patterns.

Participants in the study underwent comprehensive cognitive tests and inflammatory marker analysis, linking brain entropy changes to clinical measures of cognitive function. This meticulous approach allowed for an extensive evaluation of omega-3 supplements' role in modifying brain entropy patterns, with a focus on areas known to be involved in language and visual processing as well as emotional regulation.

Study Results

The study's findings included both anticipated and surprising elements. Despite no global cognitive improvements being detected, there was a marginal increase in processing speed noted within the omega-3 PUFAs group. Significantly, those consuming omega-3 PUFAs showed reduced brain entropy in specific brain regions like the left posterior cingulate gyrus - an area implicated in a range of cognitive functions. Furthermore, this reduction in brain entropy correlated with improvements in language abilities and a decrease in inflammatory marker IL-6, suggesting an anti-inflammatory effect of the omega-3 supplements.

Although these results only showcased a modest clinical improvement, the changes in brain entropy present intriguing implications for brain health and cognitive maintenance. The smaller sample size of the study and the marginal clinical impact highlight the need for expanded research to fully understand the potential cognitive benefits of omega-3 PUFAs supplementation.


Within the context of healthy individuals using Thrivous supplements, this study may herald a new understanding of how omega-3 PUFAs contribute to cognitive wellness. The evidence of improved processing speed and decreased brain entropy offers a compelling reason for individuals to consider omega-3 supplements as part of their daily regimen, particularly those concerned with maintaining cognitive function and reducing inflammation linked with aging.

While this study concentrates on individuals with late-life depression, the potential cognitive protective effects of omega-3 PUFAs could be extrapolated to a broader audience. Future larger scale studies may confirm these benefits, positioning omega-3 PUFAs as a key component in the quest for enhanced cognitive function and overall brain health. For those committed to optimizing their cognitive potential and promoting longevity, incorporating omega-3 PUFAs into their daily supplementation routine could prove a judicious choice.

The implications of omega-3 PUFAs for healthy cognitive aging present a beacon for ongoing research and consideration in nutritional supplementation strategies. As an eminent ally in the fight against cognitive deterioration, omega-3 PUFAs stand out as a promising supplement for anyone striving for broader human enhancement and the cherished ideal of enduring superhuman vitality and intelligence.

Thrivous Omega

Thrivous develops Omega Cardioprotector to enhance heart function and circulation for better aging. Each serving provides a clinical dose of Omega 3 Lysine Complex, which is 5 times more bioavailable than common fish oil. As suggested by this study, Omega may help to promote healthy cognitive aging. Omega Cardioprotector is available to purchase online now in the Thrivous store.

Buy Omega Cardioprotector

More Articles

Don't fall behind! Thrivous monitors new human studies of nootropic and geroprotector supplements, so you can make the best decisions based on the latest science. Supplement Science Updates are part of the free Thrivous newsletter. Subscribe now to receive email about human enhancement, nootropics, and geroprotectors, as well as company news and deals.

Read more articles at Thrivous, the human enhancement company. You can browse recent articles in Thrivous Views. See other Omega 3, Omega Cardioprotector or Supplement Science Update articles. Or check out an article below.