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This Supplement Reduces Stress

Updated 17 June 2024
Thrivous Admin


Melatonin is widely recognized for its role in regulating sleep patterns and circadian rhythms. It is naturally produced by the pineal gland in response to darkness, helping to promote sleep at night. This article delves into a scientific study that explores melatonin's broader impacts, particularly its effect on salivary cortisol and amylase, indicators of stress and digestive functioning, respectively. For a detailed read on the study, please visit the official publication.

The study in question is crucial as it expands our understanding of how melatonin could be utilized beyond just a sleep aid. The research looks into melatonin supplements and their effects on key biomarkers that could influence our overall well-being and reaction to stress. By comprehending these interactions, we could enhance our approaches to managing stress and promoting better health.

Study Design

This clinical study employed a randomized controlled trial framework to explore the effects of melatonin supplements on human subjects. A total of 64 healthy volunteers were administered a single dose of melatonin (2 mg) or a placebo at 20:00 hours in a crossover design. The saliva samples were collected at multiple time points before and after administration to measure cortisol and amylase levels, providing insight into the physiological changes occasioned by melatonin.

Participants were carefully selected based on specific inclusion criteria, and the study maintained rigorous standards to ensure reliable and valid results. The cross-over design allowed each participant to serve as their own control, enhancing the study's internal validity. The melatonin and placebo were administered in a blinded fashion to avoid any bias in the responses recorded.

Study Results

The study found that melatonin significantly improved sleep onset latency and increased total sleep time. These sleep improvements were more pronounced in participants with initially poor sleep quality. Interestingly, while melatonin administration resulted in higher cortisol levels at certain times, it demonstrated a tendency to lower alpha-amylase levels, although these changes were not statistically significant.

The results indicate a complex interaction between melatonin and the biomarkers studied. Specifically, the increase in cortisol levels at awakening suggests that melatonin might influence the body’s response to awakening. However, the mechanisms underlying these effects remain unclear, underpinning the need for further research in this area.


This study highlights the potential of melatonin not only as a sleep aid but also in modulating physiological responses associated with stress and digestion. For individuals using Thrivous supplements, particularly Serenity Nightly Nootropic, this research supports the possible benefits beyond sleep enhancement. Melatonin might help manage stress and promote a healthier circadian rhythm.

However, as with all supplements, it is recommended to consult with a healthcare provider before starting any new treatment. This is particularly important for those with underlying health conditions or those taking other medications, to ensure safe and effective use of melatonin in conjunction with other therapies.

Thrivous Serenity

Thrivous develops Serenity Nightly Nootropic to enhance relaxation and sleep. Each serving provides a clinical dose of melatonin, as well as complementary nutrients. As implied by this study, Serenity may also help to reduce stress and promote a healthier circadian rhythm. Serenity Nightly Nootropic is available to purchase online now from the Thrivous store.

Buy Serenity Nightly Nootropic

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