Geroprotectors are substances that support healthy aging, slow aging, or extend healthy life. Sometimes people refer to them as "aging suppressants," "anti-aging drugs," "gerosuppressants," "longevity therapeutics," "senolytics," or "senotherapeutics." They include various foods, nutraceuticals (supplements), and pharmaceuticals (drugs). Unfortunately none comes close to realizing the age-old aspiration of ending aging altogether (yet), but some may make a practical difference for many people.
I’ve used several geroprotectors for years. And I’m exploring ways to incorporate others into my diet, if they’re applicable to my personal situation and meet a few general criteria:
First, I look for geroprotectors supported by multiple studies on humans – not just anecdotal evidence, one study, or studies on non-human animals. Although I've nothing against the health benefits of placebo, I prefer knowing that something more than only placebo is at work.
Second, I look for geroprotectors with the highest ratios of efficacy to expense. Given innumerable options and a limited budget, I want to do more than just empty my wallet.
Third, I look for geroprotectors that are legal and generally safe. If it'll put me in a hospital or a prison, it’s not worth it.
Based on those criteria, I’ve compiled a list of top tier natural geroprotectors that actually work. These are, to the best of my knowledge, the most well-researched and effective geroprotectors available in the United States without a prescription. I’ve excluded from this list any geroprotectors that are primarily nootropic geroprotectors (such as ginkgo and melatonin), which you can find in my list of top tier nootropics. This information is for educational purposes only. It is not medical advice. Please consult a physician before and during use of these and other geroprotectors.
Berberine is a compound of extracts from herbs such as barberry. Supplementation may support healthy blood sugar and metabolic function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
- Effect of berberine administration on metabolic syndrome ...
- Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.
- Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis.
- Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Bilybum marianum: a 52-week double-blind, placebo-controlled study in obese patients with type 2 diabetes.
- The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus.
- Berberis aristata combined with Silybum marianum on lipid profile in patients not tolerating statins at high doses.
- Berberis aristata/Silybum marianum fixed combination (Berberol(®)) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: a randomized, placebo-controlled, clinical trial.
- Effects of Berberis aristata/Silybum marianum association on metabolic parameters and adipocytokines in overweight dyslipidemic patients.
- Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control.
Blueberry is the fruit of a perennial flowering plant native to North America. Supplementation may support healthy DNA and genetic function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Effect Of A Wild Blueberry (Vaccinium Angustifolium) Drink Intervention On Markers Of Oxidative Stress, Inflammation And Endothelial Function In Humans With Cardiovascular Risk Factors.
- Modulation of Nrf2-dependent gene transcription by bilberry anthocyanins in vivo.
- A Single Portion Of Blueberry (Vaccinium Corymbosum L) Improves Protection Against DNA Damage But Not Vascular Function In Healthy Male Volunteers.
- Consumption Of Blueberries With A High-carbohydrate, Low-fat Breakfast Decreases Postprandial Serum Markers Of Oxidation.
- Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome.
- Effect Of New Zealand Blueberry Consumption On Recovery From Eccentric Exercise-induced Muscle Damage.
- Effect Of Blueberry Ingestion On Natural Killer Cell Counts, Oxidative Stress, And Inflammation Prior To And After 2.5 H Of Running.
- Impact Of Multiple Genetic Polymorphisms On Effects Of A 4-week Blueberry Juice Intervention On Ex Vivo Induced Lymphocytic DNA Damage In Human Volunteers.
- The Effect Of Wild Blueberry (Vaccinium Angustifolium) Consumption On Postprandial Serum Antioxidant Status In Human Subjects.
See the Blueberry article at Examine.com for more studies and details. Also check out our article on preventing DNA damage by adding Blueberry to your diet. Blueberry is an ingredient in Thrivous Vitality Geroprotector.
3) Boswellia Serrata (Frankincense)
Boswellia Serrata is a plant native to India and Pakistan. Supplementation may support healthy joint function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- A randomized, double blind, placebo controlled, cross over study to evaluate the analgesic activity of Boswellia serrata in healthy volunteers using mechanical pain model.
- A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee.
- Clinical evaluation of Boswellia serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis).
- Comparative efficacy and tolerability of 5-Loxin and Aflapin Against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study.
- A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee.
- Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.
- Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis.
- Oral herbal therapies for treating osteoarthritis.
See the Boswellia Serrata article at Examine.com for more studies and details. Also check out our article on Boswellia for joint health. Boswellia is an ingredient in Thrivous Tenacity Arthroprotector.
Cocoa comes from the seeds of evergreen trees native to tropical regions of Central and South America. Supplementation may support healthy heart and circulatory function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Dose-dependent Increases In Flow-mediated Dilation Following Acute Cocoa Ingestion In Healthy Older Adults
- Dark Chocolate Acutely Improves Walking Autonomy In Patients With Peripheral Artery Disease
- Dark Chocolate And Vascular Function In Patients With Peripheral Artery Disease: A Randomized, Controlled Cross-over Trial
- NOX2-mediated Arterial Dysfunction In Smokers: Acute Effect Of Dark Chocolate
- Effect Of Dark Chocolate On Arterial Function In Healthy Individuals
- Flavonoid-rich Dark Chocolate Improves Endothelial Function And Increases Plasma Epicatechin Concentrations In Healthy Adults
- Acute Effect Of Oral Flavonoid-rich Dark Chocolate Intake On Coronary Circulation, As Compared With Non-flavonoid White Chocolate, By Transthoracic Doppler Echocardiography In Healthy Adults
- Cocoa Consumption For 2 Wk Enhances ... Vasodilatation Without Improving Blood Pressure ... In Essential Hypertension
- Cocoa Reduces Blood Pressure ... And Improves Endothelium-dependent Vasodilation In Hypertensives
- Blood Pressure Is Reduced ... In Glucose-intolerant, Hypertensive Subjects After 15 Days Of Consuming High-polyphenol Dark Chocolate
- Sustained Benefits In Vascular Function Through Flavanol-containing Cocoa In Medicated Diabetic Patients A Double-masked, Randomized, Controlled Trial
- Effect Of Cocoa Flavanols And Exercise On Cardiometabolic Risk Factors In Overweight And Obese Subjects
- Effects Of Dark Chocolate And Cocoa Consumption On Endothelial Function And Arterial Stiffness In Overweight Adults
- Blood Pressure And Endothelial Function In Healthy, Pregnant Women After Acute And Daily Consumption Of Flavanol-rich Chocolate: A Pilot, Randomized Controlled Trial
- Effects of Dark Chocolate and Cocoa Products on Endothelial Function: A Meta-Analysis
- Dark Chocolate Consumption Improves Leukocyte Adhesion Factors And Vascular Function In Overweight Men
- Characterisation Of Hypertensive Patients With Improved Endothelial Function After Dark Chocolate Consumption
- Consumption Of High-polyphenol Dark Chocolate Improves Endothelial Function In Individuals With Stage 1 Hypertension And Excess Body Weight
- Protective Effects Of Flavanol-rich Dark Chocolate On Endothelial Function And Wave Reflection During Acute Hyperglycemia
- Long-term Ingestion Of High Flavanol Cocoa Provides Photoprotection Against UV-induced Erythema And Improves Skin Condition In Women
Supplementation with Cocoa may also support healthy metabolic function and photoprotection, and decrease general oxidation. Evidence for these effects may not be as reliable. See the Cocoa Extract article at Examine.com for more studies and details.
5) Coenzyme Q10
Coenzyme Q10 is a molecule found in the mitochondria of humans and other organisms. Supplementation may support healthy mitochondria and cellular function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia?
- Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation.
- Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement.
- Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient.
- Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial.
- Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial.
- Effects of coenzyme Q10 supplementation on liver mitochondrial function and aerobic capacity in adolescent athletes.
Supplementation with Coenzyme Q10 may also support healthy heart and circulatory function, and decrease oxidation. Evidence for these effects may not be as reliable. See the Coenzyme Q10 article at Examine.com for more studies and details. Coenzyme Q10 is an ingredient in Thrivous Vitality Geroprotector.
Creatine is a nitrogenous organic acid that occurs naturally in vertebrates. Supplementation may enhance strength and increase hydration, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Creatine Supplementation Decreases Oxidative DNA Damage And Lipid Peroxidation Induced By A Single Bout Of Resistance Exercise
- Effect Of Creatine Supplementation On Jumping Performance In Elite Volleyball Players
- Creatine But Not Betaine Supplementation Increases Muscle Phosphorylcreatine Content And Strength Performance
- Effect Of Different Frequencies Of Creatine Supplementation On Muscle Size And Strength In Young Adults
- Beneficial Effect Of Creatine Supplementation In Knee Osteoarthritis
- Effect Of Caffeine Ingestion After Creatine Supplementation On Intermittent High-intensity Sprint Performance
- The Effects Of Polyethylene Glycosylated Creatine Supplementation On Muscular Strength And Power
- Effect Of Creatine Monohydrate In Improving Cellular Energetics And Muscle Strength In Ambulatory Duchenne Muscular Dystrophy Patients: A Randomized, Placebo-controlled 31P MRS Study
- The Effects Of Supplementation With Creatine And Protein On Muscle Strength Following A Traditional Resistance Training Program In Middle-aged And Older Men
- The Effects Of Four Weeks Of Creatine Supplementation And High-intensity Interval Training On Cardiorespiratory Fitness: A Randomized Controlled Trial
- The Effects Of Creatine Monohydrate Supplementation With And Without D-pinitol On Resistance Training Adaptations
- Effect Of Short-term Creatine Supplementation On Neuromuscular Function
- Creatine Supplementation Improves The Anaerobic Performance Of Elite Junior Fin Swimmers
- Effects Of Four Weeks Of High-intensity Interval Training And Creatine Supplementation On Critical Power And Anaerobic Working Capacity In College-aged Men
- Effects Of Creatine Monohydrate And Polyethylene Glycosylated Creatine Supplementation On Muscular Strength, Endurance, And Power Output
- Effects Of Two And Five Days Of Creatine Loading On Muscular Strength And Anaerobic Power In Trained Athletes
- Creatine Fails To Augment The Benefits From Resistance Training In Patients With HIV Infection: A Randomized, Double-blind, Placebo-controlled Study
- The Effects Of Creatine Ethyl Ester Supplementation Combined With Heavy Resistance Training On Body Composition, Muscle Performance, And Serum And Muscle Creatine Levels
- Creatine, Arginine Alpha-ketoglutarate, Amino Acids, And Medium-chain Triglycerides And Endurance And Performance
- Comparison Of Creatine Monohydrate And Carbohydrate Supplementation On Repeated Jump Height Performance
- Randomized Controlled Trial Of Dietary Creatine As An Adjunct Therapy To Physical Training In Chronic Obstructive Pulmonary Disease
- Effect Of Thirty Days Of Creatine Supplementation With Phosphate Salts On Anaerobic Working Capacity And Body Weight In Men
- Effect Of In-season Creatine Supplementation On Body Composition And Performance In Rugby Union Football Players
- Creatine Supplementation And Physical Training In Patients With COPD: A Double Blind, Placebo-controlled Study
- Creatine Supplementation Improves Muscular Performance In Older Women
- The Effects Of Creatine Loading On Thermoregulation And Intermittent Sprint Exercise Performance In A Hot Humid Environment
- Effects Of Creatine Supplementation And Three Days Of Resistance Training On Muscle Strength, Power Output, And Neuromuscular Function
- Effect Of Creatine On Swimming Velocity, Body Composition And Hydrodynamic Variables
- Resistance Training With Creatine Monohydrate Improves Upper-body Strength In Patients With Parkinson Disease: A Randomized Trial
- Effects Of Creatine Monohydrate Supplementation On Body Composition And Strength Indices In Experienced Resistance Trained Women
- Effect Of Creatine And Beta-alanine Supplementation On Performance And Endocrine Responses In Strength/power Athletes
- The Effects Of Creatine Supplementation On Selected Factors Of Tennis Specific Training
- Creatine As A Metabolic Controller Of Skeletal Muscles Structure And Function In Strength Exercises In Humans
- The Effect Of Creatine Monohydrate Supplementation On Sprint Skating In Ice-hockey Players
- The Effects Of Creatine Supplementation On Performance During The Repeated Bouts Of Supramaximal Exercise
- Does Nutritional Supplementation Influence Adaptability Of Muscle To Resistance Training In Men Aged 48 To 72 Years
- Low Dose Creatine Supplementation Enhances Sprint Phase Of 400 Meters Swimming Performance
- Creatine Monohydrate Supplementation Does Not Improve Functional Recovery After Total Knee Arthroplasty
- Creatine Supplementation During Pulmonary Rehabilitation In Chronic Obstructive Pulmonary Disease
- Effects Of Acute Creatine Loading With Or Without Carbohydrate On Repeated Bouts Of Maximal Swimming In High-performance Swimmers
- The Effects Of Acute Creatine Supplementation On Multiple Sprint Cycling And Running Performance In Rugby Players
- Effect Of Creatine Ingestion After Exercise On Muscle Thickness In Males And Females
- Effects Of Creatine Supplementation In Cystic Fibrosis: Results Of A Pilot Study
- Mg2+-creatine Chelate And A Low-dose Creatine Supplementation Regimen Improve Exercise Performance
- Effects Of Creatine On Body Composition And Strength Gains After 4 Weeks Of Resistance Training In Previously Nonresistance-trained Humans
- Effects Of High Dose Oral Creatine Supplementation On Anaerobic Capacity Of Elite Wrestlers
- The Effects Of Creatine Supplementation On Muscular Performance And Body Composition Responses To Short-term Resistance Training Overreaching
- Effects Of Creatine Supplementation And Resistance Training On Muscle Strength And Weightlifting Performance
- Effect Of Creatine And Weight Training On Muscle Creatine And Performance In Vegetarians
- Effect Of Creatine Supplementation On Body Composition And Performance: A Meta-analysis
- Effect Of Oral Creatine Supplementation On Single-effort Sprint Performance In Elite Swimmers
- Oral Creatine Supplementation Facilitates The Rehabilitation Of Disuse Atrophy And Alters The Expression Of Muscle Myogenic Factors In Humans
- Creatine Monohydrate Increases Strength In Patients With Neuromuscular Disease
- Creatine Monohydrate Supplementation Does Not Increase Muscle Strength, Lean Body Mass, Or Muscle Phosphocreatine In Patients With Myotonic Dystrophy Type 1
- Creatine Monohydrate In DM2/PROMM: A Double-blind Placebo-controlled Clinical Study. Proximal Myotonic Myopathy
- Creatine Monohydrate In ALS: Effects On Strength, Fatigue, Respiratory Status And ALSFRS
- A Randomized, Controlled Trial Of Creatine Monohydrate In Patients With Mitochondrial Cytopathies
- Creatine Has No Beneficial Effect On Skeletal Muscle Energy Metabolism In Patients With Single Mitochondrial DNA Deletions: A Placebo-controlled, Double-blind 31P-MRS Crossover Study
- Physiological Responses To Short-term Exercise In The Heat After Creatine Loading
- Effects Of Creatine Supplementation In Taekwondo Practitioners
- Effects Of Oral Creatine And Resistance Training On Serum Myostatin And GASP-1
- The Effects Of Pre Versus Post Workout Supplementation Of Creatine Monohydrate On Body Composition And Strength
- Creatine Therapy In Myophosphorylase Deficiency (McArdle Disease): A Placebo-controlled Crossover Trial
- Effects Of Creatine Supplementation On Oxidative Stress And Inflammatory Markers After Repeated-sprint Exercise In Humans
- Comparison Of Creatine Ingestion And Resistance Training On Energy Expenditure And Limb Blood Flow
- Effects Of Creatine Supplementation On Exercise Performance And Muscular Strength In Amyotrophic Lateral Sclerosis: Preliminary Results
- The Effect Of Short-term Creatine Loading On Active Range Of Movement
- Does Creatine Supplementation Hinder Exercise Heat Tolerance Or Hydration Status? A Systematic Review With Meta-analyses
- Creatine And Glycerol Hyperhydration In Trained Subjects Before Exercise In The Heat
- Creatine Supplementation Does Not Impair The Thermoregulatory Response During A Bout Of Exercise In The Heat
- Creatine Use And Exercise Heat Tolerance In Dehydrated Men
- Effects Of Creatine Supplementation On The Performance And Body Composition Of Competitive Swimmers
- Creatine Monohydrate Supplementation On Body Weight And Percent Body Fat
Supplementation with Creatine may also increase anaerobic running capacity, lean mass, bone mineral density, muscular endurance, and testosterone; and support healthy metabolic function. Evidence for these effects may not be as reliable. See the Creatine article at Examine.com for more studies and details. Creatine is also in my list of top tier nootropics.
Curcumin is the bioactive in Turmeric, which is a perennial plant native to Southern Asia. Supplementation may support joint and muscle comfort, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- A naturally-inspired, curcumin-based lecithin formulation (Meriva® formulated as the finished product Algocur®) alleviates the osteo-muscular pain conditions in rugby players.
- Curcumin and Piperine Supplementation and Recovery Following Exercise Induced Muscle Damage: A Randomized Controlled Trial.
- Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS).
- Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial.
- Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study.
- Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva(®)), nimesulide, and acetaminophen.
- Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study.
- Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients.
- Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis.
- Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis.
- Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis.
- Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Supplementation with Curcumin may also support healthy cardiovascular and joint function during normal aging. Evidence for these effects may not be as reliable. See the Curcumin article at Examine.com for more studies and details. Also check out our article on the powerful brain health benefits of Curcumin. Turmeric Curcumin is an ingredient in Thrivous Tenacity Arthroprotector.
8) DHEA (Dehydroepiandrosterone)
DHEA is a natural hormone in humans and other animals. Supplementation may increase estrogen or testosterone (depending on the need of the body), according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Dehydroepiandrosterone Combined With Exercise Improves Muscle Strength And Physical Function In Frail Older Women
- Effects Of Dehydroepiandrosterone Supplementation On Cognitive Function And Activities Of Daily Living In Older Women With Mild To Moderate Cognitive Impairment
- Effects Of Short-term Dehydroepiandrosterone Supplementation On Body Composition In Young Athletes
- Dehydroepiandrosterone Replacement Therapy In Older Adults: 1- And 2-y Effects On Bone
- Lack Of Dehydroepiandrosterone Effect On A Combined Endurance And Resistance Exercise Program In Postmenopausal Women
- Long-term Low-dose Oral Administration Of Dehydroepiandrosterone Modulates Adrenal Response To Adrenocorticotropic Hormone In Early And Late Postmenopausal Women
- Effects Of Dehydroepiandrosterone And Atamestane Supplementation On Frailty In Elderly Men
- Short-term Dehydroepiandrosterone Treatment Increases Platelet CGMP Production In Elderly Male Subjects
- Supplementation With DHEA: Effect On Muscle Size, Strength, Quality Of Life, And Lipids
- Long-term Low-dose Dehydroepiandrosterone Oral Supplementation In Early And Late Postmenopausal Women Modulates Endocrine Parameters And Synthesis Of Neuroactive Steroids
- Dehydroepiandrosterone Supplementation And Bone Turnover In Middle-aged To Elderly Men
- Six-month Oral Dehydroepiandrosterone Supplementation In Early And Late Postmenopause
- Effect Of Oral DHEA On Serum Testosterone And Adaptations To Resistance Training In Young Men
- Dehydroepiandrosterone Replacement In Healthy Men With Age-related Decline Of DHEA-S: Effects On Fat Distribution ... And Lipid Metabolism
- Androgens And Sexual Function: A Placebo-controlled, Randomized, Double-blind Study Of Testosterone Vs. Dehydroepiandrosterone In Men With Sexual Dysfunction And Androgen Deficiency
- Effects Of Dehydroepiandrosterone (DHEA) Supplementation On Hormonal, Metabolic And Behavioral Status In Patients With Hypoadrenalism
- Effects Of Dehydroepiandrosterone Vs [Drug] Supplementation In Men
- Effect Of Acute DHEA Administration On Free Testosterone In Middle-aged And Young Men Following High-intensity Interval Training
See the Dehydroepiandrosterone article at Examine.com for more studies and details.
9) Fish Oil (Omega-3)
Fish Oil, as the name suggests, is an oil that accumulates in the tissues of some fish species. Supplementation may support healthy triglyceride levels, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men.
- Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults.
- Effects of omega-3 fatty acids on postprandial triglycerides and monocyte activation.
- Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial.
- Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial.
- Metabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndrome.
- Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia.
- Treatment of rheumatoid arthritis with marine and botanical oils: influence on serum lipids.
- Effects of prescription omega-3-acid ethyl esters on fasting lipid profile in subjects with primary hypercholesterolemia.
- Prescription omega-3-acid ethyl esters reduce fasting and postprandial triglycerides and modestly reduce pancreatic β-cell response in subjects with primary hypertriglyceridemia.
- n-3 LC-PUFA-enriched dairy products are able to reduce cardiovascular risk factors: a double-blind, cross-over study.
- Effect of 6 Weeks of n-3 fatty-acid supplementation on oxidative stress in Judo athletes.
- The effects of low dose n-3 fatty acids on serum lipid profiles ... of the elderly: a randomized controlled clinical trial.
- Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes.
- Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo-controlled study.
- Effects of adding prescription omega-3 acid ethyl esters to [drug] (20 mg/day) on lipids and lipoprotein particles in men and women with mixed dyslipidemia.
- Effects of omega-3 fatty acid supplements on serum lipids, apolipoproteins and malondialdehyde in type 2 diabetes patients.
- Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects.
- Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to [drug] 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study.
- Additive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic women.
- Microalgal docosahexaenoic acid decreases plasma triacylglycerol in normolipidaemic vegetarians: a randomised trial.
Garlic is a bulbous plant native to Central Asia. Supplementation may support healthy cholesterol and heart function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Does Garlic Supplementation Control Blood Pressure in Patients with Severe Coronary Artery Disease? A Clinical Trial Study.
- The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial.
- Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial.
- Aged garlic extract improves adiponectin levels in subjects with metabolic syndrome: a double-blind, placebo-controlled, randomized, crossover study.
- Effects of Allium sativum (garlic) on systolic and diastolic blood pressure in patients with essential hypertension.
- Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial.
- The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease.
- Effects of garlic consumption on plasma and erythrocyte antioxidant parameters in elderly subjects.
- Lipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized study.
- Effects of anethum graveolens and garlic on lipid profile in hyperlipidemic patients.
- Effect of garlic (Allium sativum) oil on exercise tolerance in patients with coronary artery disease.
- Garlic supplementation prevents oxidative DNA damage in essential hypertension.
- Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study.
Supplementation with Garlic may also provide a subtle decrease to triglycerides and a strong decrease to rate of sickness. Evidence for these effects may not be as reliable. See the Garlic article at Examine.com for more studies and details. Garlic is an ingredient in Thrivous Omega Cardioprotector.
11) Horse Chestnut (Aesculus Hippocastanum)
Horse Chestnut is a deciduous flowering tree native to South East Europe. Supplementation may support healthy circulatory function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Comparison Of Leg Compression Stocking And Oral Horse-chestnut Seed Extract Therapy In Patients With Chronic Venous Insufficiency
- Horse Chestnut Seed Extract For Chronic Venous Insufficiency
- Comparative Study Of Venostasin And Pycnogenol In Chronic Venous Insufficiency
Supplementation with Horse Chestnut may also decrease pain. Evidence for this effect may not be as reliable. See the Horse Chestnut article at Examine.com for more studies and details.
Magnesium is an essential dietary mineral found in food like nuts, cereals, and vegetables. Supplementation may support healthy blood pressure, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Effect of magnesium supplementation on blood pressure: a meta-analysis.
- Oral Magnesium Supplementation Reduces Ambulatory Blood Pressure In Patients With Mild Hypertension.
- Effects Of Oral Magnesium Supplementation On ... Blood Pressure In Normo-magnesemic Nondiabetic Overweight Korean Adults.
- The Effect Of Lowering Blood Pressure By Magnesium Supplementation In Diabetic Hypertensive Adults With Low Serum Magnesium Levels: A Randomized, Double-blind, Placebo-controlled Clinical Trial.
Supplementation with Magnesium may also facilitate aerobic exercise and muscle oxygenation, and support healthy blood sugar and metabolic function. Evidence for these effects may not be as reliable. See the Magnesium article at Examine.com for more studies and details. Also check out my article on Magnesium Glycinate supplementation. Magnesium is an ingredient in Thrivous Serenity Nightly Nootropic.
Nitrate is a molecule produced in the body in small amounts and available in vegetables like beetroot. Supplementation may support healthy blood pressure, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Effect Of Dietary Nitrate On Blood Pressure, Endothelial Function ... In Type 2 Diabetes
- Effect Of Beetroot Juice On Lowering Blood Pressure In Free-living, Disease-free Adults: A Randomized, Placebo-controlled Trial
- Whole Beetroot Consumption Acutely Improves Running Performance
- Dietary Nitrate Supplementation Reduces The O2 Cost Of Walking And Running: A Placebo-controlled Study
- Effects Of Short-term Dietary Nitrate Supplementation On Blood Pressure, O2 Uptake Kinetics, And Muscle And Cognitive Function In Older Adults
- Absence Of An Effect Of High Nitrate Intake From Beetroot Juice On Blood Pressure In Treated Hypertensive Individuals: A Randomized Controlled Trial
Supplementation with Nitrate may also increase anaerobic running capacity and decrease oxygenation cost of exercise. Evidence for these effects may not be as reliable. See the Nitrate article at Examine.com for more studies and details.
14) Olive Leaf
Olive Leaf comes from an evergreen tree native to the Mediterranean, Africa, and Asia. Supplementation may support healthy cardiovascular function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Olive (Olea Europaea L.) Leaf Polyphenols Improve ... In Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial
- Olive (Olea Europaea) Leaf Extract Effective In Patients With Stage-1 Hypertension: Comparison With [Drug]
- Food Supplementation With An Olive (Olea Europaea L.) Leaf Extract Reduces Blood Pressure In Borderline Hypertensive Monozygotic Twins
- Antioxidant Effect Of Virgin Olive Oil In Patients With Stable Coronary Heart Disease: A Randomized, Crossover, Controlled, Clinical Trial
- Changes In The Phenolic Content Of Low Density Lipoprotein After Olive Oil Consumption In Men. A Randomized Crossover Controlled Trial
- The Effect Of Polyphenols In Olive Oil On Heart Disease Risk Factors: A Randomized Trial
- Postprandial LDL Phenolic Content And LDL Oxidation Are Modulated By Olive Oil Phenolic Compounds In Humans
- Effects Of Differing Phenolic Content In Dietary Olive Oils On Lipids And LDL Oxidation--a Randomized Controlled Trial
- Olive Oils High In Phenolic Compounds Modulate Oxidative/antioxidative Status In Men
- Protection Of LDL From Oxidation By Olive Oil Polyphenols Is Associated With A Downregulation Of CD40-ligand Expression And Its Downstream Products In Vivo In Humans
Supplementation with Olive Leaf may also support healthy cellular and DNA function. Evidence for these effects may not be as reliable. See the Olive Leaf Extract article at Examine.com for more studies and details.
15) Pycnogenol (Pine Bark)
Pycnogenol is an extract from bark of the maritime pine, native to the Mediterranean. Supplementation may support healthy circulation, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Normalization of cardiovascular risk factors in peri-menopausal women with Pycnogenol®.
- Management of Varicose Veins and Chronic Venous Insufficiency in a Comparative Registry with Nine Venoactive Products in Comparison with Stockings.
- Preservation of muscular mass and strength in aged subjects with Pycnogenol® supplementation.
- Effects of Pycnogenol® on endothelial dysfunction in borderline hypertensive, hyperlipidemic, and hyperglycemic individuals: the borderline study.
- A Clinical Comparison of Pycnogenol, Antistax, and Stocking in Chronic Venous Insufficiency.
- Improvement in symptoms and cochlear flow with pycnogenol in patients with Meniere's disease and tinnitus.
- Postpartum Varicose Veins: Supplementation with Pycnogenol or Elastic Compression - A 12-Month Follow-Up.
- Improvements of venous tone with pycnogenol in chronic venous insufficiency: an ex vivo study on venous segments.
- Pycnogenol® in postpartum symptomatic hemorrhoids.
- Pycnogenol® supplementation improves health risk factors in subjects with metabolic syndrome.
- Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study.
- Prevention of post thrombotic syndrome with Pycnogenol® in a twelve month study.
- Improvement in cochlear flow with Pycnogenol® in patients with tinnitus: a pilot evaluation.
- Kidney function in metabolic syndrome may be improved with Pycnogenol®.
- Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants--a controlled study.
- Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study.
- Pycnogenol treatment of acute hemorrhoidal episodes.
- Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation.
- Pycnogenol, French maritime pine bark extract, augments endothelium- dependent vasodilation in humans.
- Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study.
- Rapid relief of signs/symptoms in chronic venous microangiopathy with pycnogenol: a prospective, controlled study.
- Diabetic ulcers: microcirculatory improvement and faster healing with pycnogenol.
- Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients.
Supplementation with Pycnogenol may also support healthy joint function. Evidence for this effect may not be as reliable. See the Pycnogenol article at Examine.com for more studies and details. Also check out our article on the health benefits of Pycnogenol. Pycnogenol is an ingredient in Thrivous Omega Cardioprotector.
16) Salacia Reticulata
Salacia Reticulata is a plant native to the forests of Sri Lanka. Supplementation may support healthy blood sugar and metabolic function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Extract Of Salacia Oblonga Lowers Acute Glycemia In Patients With Type 2 Diabetes
- Effects Of A Medical Food Containing An Herbal Alpha-glucosidase Inhibitor On Postprandial Glycemia And Insulinemia In Healthy Adults
- Effects Of A Nutritional Supplement Containing Salacia Oblonga Extract And Insulinogenic Amino Acids On Postprandial Glycemia, Insulinemia, And Breath Hydrogen Responses In Healthy Adults
See the Salacia Reticulata article at Examine.com for more studies and details.
17) SAMe (S-Adenosyl Methionine)
SAMe is a naturally-occurring compound found in most tissues and fluids of the human body. Supplementation may support healthy joint function and comfort, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Comparative clinical trial of S-adenosylmethionine versus [drug] for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients.
- S-adenosyl methionine (SAMe) versus [drug] for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495].
- Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis.
Spirulina is a blue-green algae. Supplementation may support healthy cellular and cardiovascular function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Preventive Effects Of Spirulina Platensis On Skeletal Muscle Damage Under Exercise-induced Oxidative Stress
- Ergogenic And Antioxidant Effects Of Spirulina Supplementation In Humans
- A Randomized Study To Establish The Effects Of Spirulina In Type 2 Diabetes Mellitus Patients
- A Randomized Double-blind, Placebo-controlled Study To Establish The Effects Of Spirulina In Elderly Koreans
- Effects Of Dietary Spirulina On Vascular Reactivity
- Antihyperlipemic And Antihypertensive Effects Of Spirulina Maxima In An Open Sample Of Mexican Population: A Preliminary Report
- Effect Of Spirulina Maxima On Postprandial Lipemia In Young Runners: A Preliminary Report
- Hepatoprotective Effects Of Spirulina Maxima In Patients With Non-alcoholic Fatty Liver Disease: A Case Series
- Role Of Spirulina In The Control Of Glycemia And Lipidemia In Type 2 Diabetes Mellitus
- The Hypolipidemic Effects Of Spirulina (Arthrospira Platensis) Supplementation In A Cretan Population: A Prospective Study
Supplementation with Spirulina may also support healthy immune function, increase strength and endurance, decrease oxidation, and support healthy blood pressure. Evidence for these effects may not be as reliable. See the Spirulina article at Examine.com for more studies and details.
19) TUDCA (Tauroursodeoxycholic Acid)
TUDCA is a bile acid found naturally in trace amounts in humans and in large amounts in other animals like bears. Supplementation may support healthy liver function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Tauroursodeoxycholic Acid For The Treatment Of HCV-related Chronic Hepatitis: A Multicenter Placebo-controlled Study
- Ursodeoxycholic And Tauro-ursodeoxycholic Acids For The Treatment Of Primary Biliary Cirrhosis: A Pilot Crossover Study
- Tauroursodeoxycholic Acid For Treatment Of Primary Biliary Cirrhosis. A Dose-response Study
- Does Tauroursodeoxycholic Acid (TUDCA) Treatment Increase Hepatocyte Proliferation In Patients With Chronic Liver Disease
- Differences In The Metabolism And Disposition Of Ursodeoxycholic Acid And Of Its Taurine-conjugated Species In Patients With Primary Biliary Cirrhosis
Supplementation with TUDCA may also support healthy metabolic function. Evidence for this effect may not be as reliable. See the Tauroursodeoxycholic Acid article at Examine.com for more studies and details.
20) Vitamin B3 (Niacin)
Vitamin B3, also known as Niacin, is an essential dietary vitamin found in foods like liver, chicken, beef, fish, peas, peanuts, cereals, and legumes. Supplementation may support healthy cardiovascular function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Niacin In Patients With Low HDL Cholesterol Levels Receiving Intensive Statin Therapy
- Extended-release Niacin Raises Adiponectin And Leptin
- Nicotinic Acid Effects On ... Hepatic Lipid Metabolism: An In Vivo To In Vitro Study
- Effects Of Nicotinic Acid On ... Blood Pressure In Healthy Subjects
- Short-term Effects Of Extended-release Niacin With And Without The Addition Of Laropiprant On Endothelial Function In Individuals With Low HDL-C: A Randomized, Controlled Crossover Trial
- Niacin, But Not [Drug], Selectively Increases LP-AI, A Cardioprotective Subfraction Of HDL, In Patients With Low HDL Cholesterol
- Effect Of [Drug] And Niacin On Intrahepatic Triglyceride Content, Very Low-density Lipoprotein Kinetics ... In Obese Subjects With Nonalcoholic Fatty Liver Disease
- Clofibrate And Niacin In Coronary Heart Disease
Supplementation with Vitamin B3 may also support healthy blood sugar and metabolic function. Evidence for these effects may not be as reliable. See the Vitamin B3 article at Examine.com for more studies and details. Also check out my article on Vitamin B supplementation.
21) Vitamin D
Vitamin D is an essential dietary vitamin naturally synthesized in the skin from sun exposure. Supplementation may decrease risk of falls, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Fall Prevention With Supplemental And Active Forms Of Vitamin D: A Meta-analysis Of Randomised Controlled Trials
- A Higher Dose Of Vitamin D Reduces The Risk Of Falls In Nursing Home Residents: A Randomized, Multiple-dose Study
- Low-dose Vitamin D Prevents Muscular Atrophy And Reduces Falls And Hip Fractures In Women After Stroke: A Randomized Controlled Trial
Supplementation with Vitamin D may also increase functionality in the elderly, support healthy blood pressure, and support healthy bone function. Evidence for these effects may not be as reliable. See the Vitamin D article at Examine.com for more studies and details.
22) Vitamin K
Vitamin K is an essential dietary vitamin found in foods like leafy green vegetables and some fruits. Supplementation may support healthy bone function, according to multiple peer-reviewed, double-blind, placebo-controlled studies in humans:
- Dietary intake of vitamin K in relation to bone mineral density in Korea adults: The Korea National Health and Nutrition Examination Survey (2010-2011).
- Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
- Menatetrenone versus [drug] in the treatment of Chinese postmenopausal women with osteoporosis: a multicenter, randomized, double-blinded, double-dummy, positive drug-controlled clinical trial.
- Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
- Dietary vitamin K2 supplement improves bone status after lung and heart transplantation.
- Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women.
- Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia.
- Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG).
- Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age.
- Effect of continuous combined therapy with vitamin K(2) and vitamin D(3) on bone mineral density and coagulofibrinolysis function in postmenopausal women.
- Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.
- Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
Because it can be unnecessarily tedious and expensive to find, buy, measure, and swallow these geroprotectors separately, Thrivous is incorporating them into convenient, premium-quality, cost-effective products with science-based doses that reflect the results of the studies shared above. It's part of our mission to help you access technology with the greatest potential to improve your brain and body. If you'd like to be notified as these products become available, please sign up for our newsletter.
Thrivous currently offers four geroprotector products. We formulated Vitality Geroprotector to support healthy metabolic, cellular, and genetic function. We formulated Tenacity Arthroprotector to support healthy joint and bone function. We formulated Alpha Neuroprotector to support healthy brain and nerve function. And we formulated Omega Cardioprotector to support healthy circulation, cholesterol, triglycerides, and heart function.
You can get Vitality, Tenacity, and Omega in Geroprotector Stack at a large discount. Geroprotector Stack provides most of the geroprotectors in this list at effective doses, along with complementary nutrients to improve their overall efficacy. Talk to your doctor about starting Thrivous geroprotectors today!